chemistry

Orca's selective RORγ inhibitors block the differentiation of human Th17 cells without affecting differentiation of Th1 cells.

In collaboration with Dr Fraydoon Rastinejad at the Sanford-Burnham Medical Research Institute (SBMRI) in Lake Nona, Florida, we are now using high-resolution crystal structures of some of our compounds bound to RORγt to optimise our current leads and develop new classes of inhibitor.
Key attributes of the Orca lead compound:

  • Patent-protected
  • Highly potent (nanomolar) inhibitor of RORγt activation with selectivity against other related nuclear hormone receptors
  • Inhibits differentiation of Th17 cells in vitro and in vivo
  • Acceptable in vitro ADME characteristics amenable to further optimization